February 21, 2018
People suffering from a major depressive disorder, MDD, have reduced arginine levels, a new study from the University of Eastern Finland shows. Arginine is an amino acid which the body uses to produce, e.g., nitric oxide. Nitric oxide, in turn, is a nervous system and immune defense mediator, and it also plays a role in vascular regulation. The global arginine bioavailability ratio, GABR, is an indicator of the body's arginine levels, and the ratio has previously been used to measure the body's capacity to produce nitric oxide. Reduced arginine bioavailability is also known to be an independent risk factor of cardiovascular diseases.  (source:

Nitric oxide


Nitric oxide (NO) is an important molecule we need in our system for many functions. The production of our Bio-nitric oxide decreases as we age and as a result of fewer enzymes (not age-related !). 


The Humming Mask is helping to raise the NO level by using our Bio-NO available in our sinuses.  By daily use just before sleep, we can use the mask to increase our NO what will help reducing depression various tests shows. There is also evidences that even people with anxious combined with depression, will benefit over time.   

You are free to try the mask without any risk as you have a 30-day return warranty when you order through Amazon Prime.   

You can read more details about the role of nitric oxide and how the Humming Mask can help you on this site. 



Nitric oxide has been known to play a significant role in the pathophysiology of various disorders of the body. Despite its very short half-life, Nitric oxide is known to modulate various neurotransmitter system(s) in the body and thus is speculated to play an imperative role in the pathogenesis of neurological disorders. This “miracle” molecule has been often found to play a “dual role” in many neurological disorders of the body. Evidence has shown its prominent role in the pathogenesis of major depression. Nitric oxide modulates norepinephrineserotonin, dopamine, glutamate, the major neurotransmitters involved in the neurobiology of major depression. The nitric oxide modulatory activity of various new generations of antidepressants has been demonstrated. Clinical studies have also confirmed the nitric oxide modulatory activity of various antidepressants particularly belonging to the class of selective serotonin reuptake inhibitors. The present review attempts to discuss the role of nitric oxide in the pathophysiology of major depression. Further, the involvement of the Nitric oxide system in the mechanism of various antidepressants has been discussed in detail. Nitric oxide-based antidepressants can be the future drugs of choice for major depression, particularly in the treatment of pharmacoresistant depression.